Liver Targeting Novel Trends In Therapies

Abstract

Dr Jaya Agnihotri, Mahima Salian, Janhavi Mishra, Mohd Anas Shaikh and Shaikh Mohd Fareed

Background: In this review Novel strategies for site-specific delivery of active pharmaceutical ingredients to different types of liver cells like Hepatic stellate cells [HSCs], active Kupffer cells, sinusoidal endothelial cells etc. have been discussed. The most prevalent liver ailments are hepatitis, alcoholic or non-alcoholic liver disease, hepatocellular carcinoma, hepatic venous-occlusive disease, liver fibrosis, and cirrhosis.

Method: Literature was searched through various online resources for the recent advances in liver-targeted site-specific delivery using various approaches. We focused on the use of novel targeted delivery to improve Drug efficacy, dose reduction and Rapid onset of action.

Results: Novel medicines aim to minimize unfavorable side effects by either sustaining drug action at a set rate or delivering the drug at a suitable time in the body. Therapeutic nanocarriers and their surface modification with particular ligands including carbohydrates, peptides, proteins, and antibodies are two main strategies that have been suggested to optimize the transport of various medications to the liver and hepatocytes. It subsequently lowers the toxicity and prolongs the drug's time in the systemic circulation.

Conclusion: The current review provides information on various liver illnesses as well as the targeting techniques used to concern hepatic anatomy and disease etiologies.

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