Is there an association of bone mineral density and risk of breast cancer in postmenopausal Saudi women?

Abstract

Saleh Othman*

Several studies revealed an association between high bone mineral density (BMD) and the increased risk for developing breast cancer (BC).

Aim: Explore if there is an association between BMD and BC risk in postmenopausal Saudi (PMS) women.

Material and Method: In a retrospective cohort study of 1145 PMS women age range from 46 – 85 year (mean = 55 year). The average time period of menopause 4 years.We reviewed BMD of all patients performed between October 2012 and November 2018. All patients had BMD measurements of lumbar spine L2-L4 and right femoral neck in gm/cm².

Results: The T-score was used for analysis of the results. Among the total patient studied 195 (17%) were found to have BC group 1 (G1) while 950 (93%) without BC group 2(G2). Analysis of lumbar spine T-score in G1 showed that: 29 % had osteoporosis, 37% osteopenia and 34% had normal BMD and in G2 40% had osteoporosis, 31% osteopenia and 29 had normal values. Results showed prevalence of osteoporosis in G1 was significantly lower than in G2 (p =0.002) while there was no significant difference between the two groups with osteopenia and normal BMD results (p = 0.06 and 0.205 respectively).

Conclusion: PMS women with BC had higher BMD at time of diagnosis compared to their counterpart without BC.

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