Evaluation of Carotid Intima-Media Thickness in Maintenance Hemodialysis Patients in Dakar (West Africa)

Abstract

Lengani H A*, Balde M S, Mingou J S, Kane Y, Mbaye A, Cisse M M, Ka E H F, Niang A and Diouf B

Objective: To evaluate carotid intima-media thickness (CIMT) and its association with cardiovascular risk factors (CVRFs) in chronic hemodialysis patients.

Patients and methods: This cross-sectional study was conducted over a period of six months at the hemodialysis unit of University Hospital Aristide Le Dante in Dakar, Senegal. CIMT was measured using a B mode ultrasonography.

Results: Fifty-seven patients, with a mean age of 48.36±14.93 years, 42.1% male, were included. The sex ratio was 0.72%. The mean CIMT was 0.835±0.21 mm. Increased CIMT was associated with older age (p=0.004), history of smoking (p=0.034), peripheral artery disease (p=0.02), and elevated pre- and post-dialysis systolic blood pressure and pulse pressure (p<0.05 for all). No association was found with dyslipidemia, C-reactive protein (CRP), phosphate, or intact parathyroid hormone (it) levels.

Conclusion: CIMT is a marker of subclinical atherosclerosis in hemodialysis patient. It may help in cardiovascular risk stratification, particularly in older patients, smokers and those with a history of PAD, or elevated blood pressure.

HTML PDF