Can Serum Uric Acid Predict Prediabetes in Adult Males? A Case Control Study

Abstract

Methaq H Alogaili, Atheer J Alsaffar, Nibras Alaa Hussain

It is well known that serum uric acid (SUA) involved in the met- abolic dysregulations which leads to the development of type 2 diabetes mellitus (T2DM) but this relation is not fully explored with prediabetes (PreDM) which is a metabolic state characterized by higher than normal glucose level but not enough to be consid- ered as diabetes [1,2]. About two-thirds of those with preDM will progress to T2DM [3]. Those with preDM are almost identical (re- garding risk factors) to those with T2DM (advanced age, obesity and diminished physical activity...etc.) and also are predisposed to develop both micro and macrovascular complications of overt T2DM [4]. Accumulation of SUA in excess play key role in the pathogenesis of metabolic syndrome (overweight, elevated blood pressure, dyslipidemia and abnormal glucose metabolism) [5]. The Preventive Cardiology Information System (PreCIS) database assured that for each one mg/dl rise in the SUA level, there was increase in the risk of death by 39% and even after adjusting for other cardiovascular risk factors, the SUA level continued to pre- dict the risk of death [6].

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