A Partial View of the Gut-Brain Axis Study from Lifestyle Details Through Metabolic Disorders to Dementia Using Viscoplastic Energy Model of GH-Method: Math-Physical Medicine (No. 1015, Viscoelastic Medicine Theory #413)

Abstract

Gerald C. Hsu

The gut-brain axis is essential for regulating metabolism, which can impact the development of type 2 diabetes (T2D) and obesity, both of which are linked to dementia, particularly in the context of neurodegenerative conditions such as Alzheimer's and Parkinson's. In short, the gut-brain axis influences various brain functions, including cognition and motor control.

As a long-term T2D patient without access to medical facilities, instruments, or the means to collect and analyze specific gut-brain axis biomarkers like gut hormones (ghrelin, leptin, cholecystokinin, peptide YY), gut motility, gut microbiota information, and pathological brain proteins such as beta-amyloid and tau, the author relied on available and collectible data as a patient. For example, both obesity and diabetes represent not only metabolic disorders associated with insulin resistance but also demonstrate situations of low-grade inflammation. Additionally, fasting plasma glucose in the early morning (FPG) was used as an indicator of the level of insulin resistance. The author also chose to incorporate the TyG index (Triglyceride-glucose index) as a biomarker for both insulin resistance (TyG value greater than 4.49) and non-alcoholic fatty liver disease (NAFLD, TyG value greater than 8.5).

PDF