Journal of Clinical & Experimental Immunology(JCEI)
ISSN: 2475-6296 | DOI: 10.33140/JCEI
Impact Factor: 1.9
T-Cells Levels after Previous Covid-19 Infection and Vaccination in Health Workers in Cote D'ivoire
Abstract
Yeboah Oppong Richard, Dasse Sery Romuald, Goran-Kouacou Amah, Patricia Victorine, Adou Adjoumanvoule Honore, Assi Aya Ursule Aniela, Seri Yida Jocelyne, Memel Lasme Roselle Charline, Koya Herbert, Gautier, Moussa Salimata, Oura Brou Doris, Nâguessan Koffi and Siransy Kouabla Liliane
Justification : The only means of acquiring protective immunity against SARS-CoV-2 are infection and vaccination. Intensive research is being carried out to understand the similarities and variations in the immune response in naturally recovered patients and after vaccination. Comparing T-cell levels during these two forms of immunisation could provide a better understanding of the cellular immune response induced by each.
Methods : This was a descriptive and analytical cross-sectional study on healthcare workers in the 3 hospitals and university centres of Abidjan. A total of 275 regularly assigned health workers were randomly selected for inclusion. Survey forms were completed, vaccination records were consulted for those vaccinated and blood samples were taken. T lymphocyte counts and cytokine assays were performed using flow cytometry. The Kruskal-Wallis test was used to compare the medians.
Results : CD4+ counts were significantly higher in vaccinated subjects compared with non-vaccinated subjects and those with a history of infection. On the other hand, CD8+ TL levels were significantly higher in subjects with a history of infection and especially in those with hybrid immunisation compared with those with vaccination as the only type of immunisation.
In terms of pro-inflammatory cytokines, hybrid immunisation led to an increase in IL-6 and TNF levels. However, IFN levels were lower. In terms of anti-inflammatory cytokines, IL2 levels were higher with hybrid immunisation, but IL-10 levels were lower.
Conclusion : CD4+ T lymphocyte levels were higher during vaccination and hybrid immunisation, whereas CD8+ T lymphocyte levels were higher during infection and hybrid immunisation.