Journal of Clinical Review & Case Reports(JCRC)
ISSN: 2573-9565 | DOI: 10.33140/JCRC
Impact Factor: 1.823
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Tardive Dyskinesia and Akathasia: A Dopamine System Theory Clinical Review
Abstract
Tammi McGill-Carter
Long term use of first generation anti-psychotics (FGAs) have been theorized in the formation of motion disorders Tardive Dyskinesia and Akathasia and due to the breakdown in the extra pyramidal system (EPS) located in the Basal Ganglia [1]. The second generation anti-psychotics (SGAs) were sourced to be the “treatment” of TD by blocking dopamine receptors with dopamine agonists of the D2-D5 receptors while also being seen as the genesis of AK. However, the blocking of the receptors in both motion disorders is a theory known as the dopamine blockage theory, despite the intermingle of other neurotransmitters such as Serotonin and Norepinephrine [2]