Neurological Stimulation of Certain Brain Functions and Related Models of Neuroendocrine Simulations Using both Neurology Knowledge and Viscoplastic Energy Model of GH-Method: Math-Physical Medicine (No. 1031, Viscoelastic Medicine Theory #429)

Abstract

Gerald C. Hsu

The author's paper number 094 published in 2019 addressed certain brain stimulation and simulation models of the endocrine system using data collected over a 5-year period, from 2015 to 2019. The author has since revisited the same subject with his expanded understanding of brain functions, incorporating additional data collected over a span of 10 years, from 2015 to 2024. Additionally, he utilized an energy model associated with the space-domain viscoplastic medicine theory (SD-VMT) to provide quantitative findings regarding relationships among certain specific endocrine biomarkers that are controlled and regulated by the brain.

The brain plays a pivotal role in regulating energy balance, glucose metabolism, and insulin sensitivity through the coordination of various neurological pathways, including neuronal circuits in hypothalamus, the autonomic nervous system, neuroendocrine regulation, brain-gut interaction, and behavioral regulation. Furthermore, the brain also plays a central role in regulating blood pressure and blood lipid metabolism through the coordination of various neural pathways and signaling molecules, such as the autonomic nervous system, baroreflex mechanism, neuroendocrine regulation, and neuroimmune interactions.

In short, the brain processes its received information regarding food and water consumed and bowel movement the previous day and sleep conditions at night to determine the next morning's body weight, which directly affects the fasting plasma glucose (FPG) level in the early morning. Throughout the day, the brain continuously receives further inputs, such as the amount of carbohydrates and sugar intake, physical activity level, ambient temperature, stress and more (20+ other factors), to make its decisions and provide "marching orders" to the liver for glucose production and the pancreatic beta cells for insulin production. This process alters the level of postprandial plasma glucose (PPG). Additionally, the brain also plays a role in regulating blood pressure and cholesterol levels.

An excerpt of the abstract of his paper No.094 and additional detailed biomedical information regarding the brain's neurological functions related to the endocrine system are included in the Introduction Section of this article. Over the past 10 years, the author developed numerous accurate and practical simulation models and achieved predicted results for certain endocrine biomarkers, such as body weight, FPG, and PPG. These predicted results have very high prediction accuracies (most of them above 99%) and high correlations between measured and predicted biomarker values (above 70%, except for PPG at 46%).

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