Exosome Therapy for Hair Loss

Abstract

Mohammed Al Abadie, N Abed and M Mahfoudh

Hair loss is a widespread condition impacting millions globally, often causing considerable psychological and social stress. Traditional treatments like minoxidil and finasteride face challenges due to variable effectiveness and possible side effects, leading to an interest in innovative regenerative therapies. Exosomes, tiny extracellular vesicles released by diverse cell types, have gained attention for their role in cell communication and their capacity to influence critical biological processes, like inflammation and cell growth. This review delves into the use of exosomes for treating hair loss, elaborating on their mechanisms, such as activating hair follicle stem cells, fostering angiogenesis, decreasing inflammation, and reducing oxidative stress. Findings from both preclinical and clinical research underline their potential to improve hair density, thickness, and scalp condition, with few negative side effects. The review also touches on obstacles like exosome isolation standardization, scalability, and long-term safety, proposing potential solutions, including advancements in exosome engineering and combination therapies. Looking ahead, there's an emphasis on the necessity for extensive clinical trials and the integration of exosome therapy with other regenerative approaches. This treatment showcases a cutting-edge, minimally invasive method with incredible potential to transform hair loss management loss.

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