Epstein Barr Virus Associated with Hashimotos Thyroiditis and Treated with a Novel Nanobiological Therapy Based on Micro RNAs A Case Report

Abstract

GLADY Gilbert

Hashimoto’s thyroiditis, on the one hand, represents one of the most common autoimmune diseases in general, and on the other hand displays a proven genetic and environmental determinism. Its prevalence has been rising up in the last decades everywhere and the disease shows multifactorial etiologies. For some time now, different viruses have been regularly mentioned among the environmental factors involved in the onset of the disease, but it is only recently that Epstein-Barr Virus, a common human herpes virus known to infect most of the world population, has been mentioned in this context of human pathology, while its participation during its latency phase is more and more often demonstrated in a growing number of autoimmune diseases. MicroRNAs (miRNAs) are small noncoding endogenously produced RNAs that play key roles in controlling the expression of many cellular genes at a post-transcriptionally level. After cytoplasmic recruitment and incorporation into a ribonucleoprotein complex, they can target specific mRNAs and interfere in their translation into proteins. Consequently, miRNAs can regulate many cellular pathways and processes, and their dysregulation may largely contribute to several kinds of diseases, particularly those related to autoimmune mechanisms. We will show with the help of a clinical case that such a pathological association can be regulated thanks to a new method of immunotherapy in ultra-low doses

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