Oxidative stress, defined as a disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defenses, is discussed in relation to its possible role in the production of tissue damage in diabetes mellitus. Several studies have suggested that oxidative stress could play a role in the pathogenesis of nonalcoholic fatty liver disease and more precisely in the transition between simple fatty liver and steatohepatitis. Some studies have suggested that, apart from endotoxins, cytokines, hyperlipidemia and hyperinsulinemia, oxidative stress could play a role in the pathogenesis of Nonalcoholic Fatty Liver Disease (NAFLD) and more precisely in the transition between simple fatty liver and steatohepatitis (i.e. fatty liver coexistent with hepatocyte necrosis and inflammation). Innovations are new idea, device or process. Innovations are the application of better solutions that meet new requirements, inarticulated needs or existing market needs.